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Dean downey negative pressure wound therapy11/10/2023 ![]() We investigated the combination of ceritinib and ribociclib on in vitro proliferation, cell cycle, viability, caspase activation, and the cyclin D/CDK4/CDK6/RB and pALK signaling networks in cell lines with representative ALK status. We performed an in vitro screen for synergistic drug combinations that target neuroblastomas with mutations in ALK to determine whether drug combinations could enhance antitumor efficacy.Experimental Design: We screened combinations of eight molecularly targeted agents against 17 comprehensively characterized human neuroblastoma-derived cell lines. Purpose: Anaplastic lymphoma kinase (ALK) is the most frequently mutated oncogene in the pediatric cancer neuroblastoma. The use of detected physiological cycle phases to synchronize locomotion of HeartLander is also described. Improved performance is demonstrated in comparison to the filtering methods previously used with HeartLander. The proposed method is demonstrated in the laboratory with HeartLander operating on a physiological motion simulator. The work presented uses an Extended Kalman Filter framework to estimate parameters of non-stationary Fourier series models of the motion of the heart due to the respiratory and cardiac cycles as well as the position of the robot as it moves over the surface of the heart. This mode of operation does not require physiological motion compensation to provide this stable environment however, modeling of physiological motion is advantageous in providing more accurate position estimation as well as synchronization of motion to the physiological cycles. ![]() ![]() This is achieved inherently in the way the robot adheres to and crawls over the surface of the heart. HeartLander, a small mobile robot designed to provide treatments to the surface of the beating heart, overcomes a major difficulty of minimally invasive cardiac surgery, providing a stable operating platform.
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